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TB-500
parameters1:
parameters2:
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2mg/vial,10vials/kit
5mg/vial,10vials/kit
10mg/vial,10vials/kit

TB-500 is an actin-sequestering peptide that modulates inflammation and healing in different tissues. It plays a major role in angiogenesis and tumor metastasis. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y (TMSB4Y). Beta thymosins are a family of proteins which have in common a sequence of about 40 amino acids similar to the small protein thymosin β4.

 

TB-500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells. An additional key factor of TB-500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.

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